PUBLICATIONS

Synthetic yeast chromosome XI design enables extrachromosomal circular DNA formation on demand.

Benjamin A Blount, Xinyu Lu, Maureen R M Driessen, Dejana Jovicevic, Mateo I Sanchez, Klaudia Ciurkot, Yu Zhao, Stephanie Lauer, Robert M McKiernan, Glen-Oliver F Gowers, Fiachra Sweeney, Viola Fanfani, Evgenii Lobzaev, Kim Palacios-Flores, Roy Walker, Andy Hesketh, Stephen G Oliver, Yizhi Cai, Giovanni Stracquadanio, Leslie A Mitchell, Joel S Bader, Jef D Boeke, Tom Ellis. Submitted.

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An engineered transcriptional reporter of protein localization identifies regulators of mitochondrial and ER membrane protein trafficking in high-throughput screens.

Coukos R, Yao D, Sanchez MI, Strand ET, Weissman JS, Bassik MC, Ting AY. Elife 2021, 10e69142.

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A molecular calcium recorder reveals unique cell type in brain striatum underlying aversion.

Kim CC*, Sanchez MI*, Hoerbelt P, Malenka RC, Deisseroth K, Ting AY. Cell 2020, 183, 2003.

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Transcriptional readout of neuronal activity via an engineered Ca+2-activated protease.

Sanchez MI, Wang W, Nguyen Q.-A, Soltesz I, Ting AY. PNAS 2020, 117, 33186.

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Directed evolution improves the catalytic efficiency of TEV protease.

Sanchez MI, Ting AY. Nat. Methods 2020, 17, 167.

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MitoBlue as a tool to analyze the mitochondria-lysosome communication.

Sanchez MI, Vida Y, Perez-Inestrosa E, Vazquez ME, Mascareñas JL, Sugiura A, Martinez-Costas J. Sci. Rep. 2020, 10, 3528.

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Novel broad-spectrum activity-based probes to profile malarial cysteine proteases.

Tan MSY, Davison D, Sanchez MI, Anderson BM, Howell S, Snijders A, Edgington-Mitchell LE, Deu E. PLoS One 2020, 15, e0231231.

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Identification of Plasmodium dipeptidyl aminopeptidase allosteric inhibitors by high throughput screening.

Sanchez MI, de Vries LE, Lehmann C, Lee JT, Ang KK, Wilson C, Chen S, Arkin MR, Bogyo M, Deu E. PLoS One 2019, 14, e0226270.

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Canonical DNA minor groove insertion of bisbenzamidine-Ru(II) complexes with chiral selectivity.

Sanchez MI, Rama G, Calo R, Ucar K, Lincoln P, Vázquez López M, Melle-Franco M, Mascareñas JL, Vázquez ME. Chem. Sci. 2019, 10, 8681-8674.

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Characterization of P. falciparum dipeptidyl aminopeptidase 3 specificity identifies differences in amino acid preferences between peptide-based substrates and covalent inhibitors.

de Vries LE, Sanchez MI*, Groborz K, Kuppens L, Poreba M, Lehmann C, Nevins N, Withers-Martinez C, Hirst DJ, Yuan F, Arastu-Kapur S, Horn M, Mares M, Bogyo M, Drag M, Deu E. FEBS J. 2019 febs.14953.

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Plasmodium falciparum dipeptidyl aminopeptidase 3 activity is important for efficient erythrocyte invasion by the malaria parasite.

Lehmann C, Tan MSY, de Vries LE, Russo I, Sanchez MI, Goldberg DE, Deu E. PLoS Pathog. 2018 14, e1007031.

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Time-gated detection of protein-protein interactions with transcriptional readout.

Kim MW, Wang W, Sanchez MI, Coukos R, von Zastrow M, Ting AY. Elife. 2017, 6:e30233.

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A light- and calcium-gated transcription factor for imaging and manipulating activated neurons.

Wang W, Wildes CP, Pattarabanjird T, Sanchez MI, Glober, GF, Matthews GA, Tye KM, Ting AY. Nature Biotechnology, 2017, 35, 864-871.

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Light-Controlled Cellular Internalization and Cytotoxicity of Nucleic Acid-Binding Agents: Studies in Vitro and in Zebrafish Embryos.

Penas C, Sanchez MI, Guerra-Varela J, Sanchez L, Vázquez ME, Mascareñas JL. Chembiochem. 2016, 1, 37.

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Sequence-Selective DNA Binding with Cell-Permeable Oligoguanidinium-Peptide Conjugates.

Mosquera J, Sanchez MI, Vazquez ME, Mascareñas JL. Chem. Commun. 2015, 51, 4841-4.

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Synthetic peptides caged on histidine residues with a bisbipyridyl ruthenium(ii) complex that can be photolyzed by visible light.

Mosquera J*, Sanchez MI *, Vazquez ME, Mascareñas JL. Chem. Commun. 2015, 51, 5501.

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Design of a highly selective quenched activity-based probe and its application in dual color imaging studies of cathepsin S activity localization.

Oresic Bender K, Ofori L, van der Linden WA, Mock ED, Datta GK, Chowdhury S, Li H, Segal E, Sanchez Lopez M, Ellman JA, Figdor CG, Bogyo M, Verdoes M. J. Am. Chem. Soc. 2015, 137, 4771.

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Fluorescence-Labeled Bis-benzamidines as Fluorogenic DNA Minor-Groove Binders: Photophysics and Binding Dynamics.

Bordello J, Sanchez MI, Vázquez ME, Mascareñas JL, Al-Soufi W, Novo M. Chem. Eur. J. 2015, 21, 1609.

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MitoBlue: A Nontoxic and Photostable Blue-Emitting Dye That Selectively Labels Functional Mitochondria

Sanchez MI, Martínez-Costas J, González F, Bermúdez MA, Vázquez ME, Mascareñas JL. ACS Chem Biol. 2014, 9, 2742.

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Reversible Supramolecular Assembly at Specific DNA Sites: Nickel-Promoted Bivalent DNA Binding with Designed Peptide and Bipyridyl–Bis(benzamidine) Component.

Sanchez MI *, Mosquera J*, Vazquez ME, Mascareñas JL. Angew. Chem. Int. Ed. Engl. 2014, 53, 9917.

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Ruthenium bipyridyl complexes as photocleavable dimerizers: deactivation of DNA-binding peptides using visible light.

Mosquera J*, Sanchez MI *, Vazquez ME, Mascareñas JL. Chem. Commun. 2014, 50, 10975.

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Metal-catalyzed uncaging of DNA-binding agents in living cells.

Sanchez MI, Penas C, Vazquez ME, Mascareñas JL. Chem. Sci. 2014, 5, 1901.

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Custom-Fit Ruthenium(II) Metallopeptides: A New Twist to DNA Binding With Coordination Compounds.

Gamba I, Salvado I, Rama G, Bertazzon M, Sanchez MI, Sanchez-Pedregal VM, Martinez-Costas J, Brissos RF, Gamez P, Mascareñas JL, Vazquez Lopez M, Vazquez ME. Chem. Eur. J. 2013, 19, 13369.

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Site-specific protein labeling using PRIME and chelation-assisted click chemistry.

Uttamapinant C, Sanchez MI, Liu DS, Yao JZ, Ting AY. Nat. Protoc. 2013, 8, 1620.

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Sequence-Selective DNA Recognition with Peptide–Bisbenzamidine Conjugates.

Sanchez MI, Vázquez O, Vazquez ME, Mascareñas JL. Chem. Eur. J. 2013, 19, 9923.

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Single-Molecule Approach to DNA Minor-Groove Association Dynamics.

Bordello J, Sanchez MI, Vázquez ME, Mascareñas JL, Al-Soufi W, Novo M. Angew. Chem. Int. Ed. Engl. 2012, 51, 7541.

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Straightforward access to bisbenzamidine DNA binders and their use as versatile adaptors for DNA-promoted processes.

Sanchez MI, Vazquez O, Martínez-Costas J, Vazquez ME, Mascareñas JL. Chem. Sci. 2012, 3, 2383-2387.

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In Vivo Light-Driven DNA Binding and Cellular Uptake of Nucleic Acid Stains.

Sanchez MI, Martínez-Costas J, Gonzalez F, Bermudez MA, Vazquez ME, Mascareñas JL. ACS Chem Biol. 2012, 7, 1276.

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Light-controlled DNA binding of bisbenzamidines.

Sanchez MI, Vázquez O, Vázquez ME, Mascareñas JL. Chem. Commun. 2011, 47, 11107.

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dsDNA-triggered energy transfer and lanthanide sensitization processes. Luminescent probing of specific A/T sequences.

Vázquez O, Sanchez MI, Mascareñas JL, Vazquez ME. Chem. Commun. 2010, 46, 5518.

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Bis-4-aminobenzamidines: Versatile, Fluorogenic A/T-Selective dsDNA Binders.

Vazquez O, Sanchez MI, Martinez-Costas J, Vazquez ME, Mascareñas JL. Org. Lett. 2010, 12, 216.

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Highly Diastereoselective Katsuki−Jacobsen Oxidation−Epoxidation of α-Silyloxy Sulfinyl Dienes: Synthetic Applications.

Fernández de la Pradilla R, Castellanos A, Osante I, Colomer I, Sanchez MI. J. Org. Chem. 2009, 74, 170.

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About the lab

We are a chemical biology lab, located at the University of Cambridge, that aims to apply the principles of chemistry in order to unlock our understanding of cell biology and using biology to create new chemistry.  

Localization

University of Cambridge
Department of Chemistry
Lensfield Road, Cambridge CB2 1EW, UK